When sending out high volume email advertisements, you will most definitely want to create multiple campaigns. Velocity software features tracking software that allows you to see how successful your current campaign is going. While that is going on, you can keep creating campaigns and save them for later. If your current campaign is not going as successful as you thought, then this gives you the option to simply edit future campaigns instead of having to create all new ones. If people react favorably to your first campaign, then you could consider adding more incentive into your future campaigns.
It is always good to have multiple campaigns ready to send out. You can direct different campaigns to different lists if you choose. It is important to use the tracking feature to gauge precisely what your audience seems most interested in order to obtain the most profit from your campaign.